Day 1 :
Keynote Forum
Toluleke Famuyiwa
Florida Atlantic University, USA
Keynote: ABC transporters mediated multidrug resistance in prostate cancer cells
Time : 09:00 AM
Biography:
Toluleke Famuyiwa is the CEO of Solution Illuminators LLC and a John Maxwell Certified Coach, Trainer, and Speaker. He is certified as a competent communicator by Toastmasters International. He is mentoring undergraduate students in the USA and Nigeria. He does mastermind workshops, seminars, keynote speaking, and coaching. He holds a Master of Science Degree in Biology. He is currently a PhD student in Integrative Biology at Florida Atlantic University. He is an Adjunct Instructor at Broward College. He is a member of the following professional association: American Association for the Advancement of Science (AAAS); Health, Wellness & Society Research Network; American Society for Biochemistry and Molecular Biology (ASMB); Society for Integrative and Comparative Biology (SCIB); American Society of Clinical Oncology (ASCO); American Society for Pharmacology and Experimental Therapeutics (ASPET). He held numerous leadership positions; President of National Animal Science Students Association (NASSA) as an Undergraduate in Nigeria; C-BAC chairperson at Broward House of Representative, FAU; Assistant Director of Graduate and Professional Students’ Association (GPSA). He is a recipient of outstanding student volunteer of the year; M- DOT award; Idiculla John Broward Student Employee Impact Award; numerous fellowships at FAU.
Abstract:
Background: Prostate cancer is the second most diagnosed cancer. This study focuses on overcoming ATP Binding Cassette (ABC)-mediated drug resistance in prostate cancer treatment. The objective of study: This study aims to (i) investigate the interaction between 3-BPA and SC-514, (ii) reduce treatmentinduced ABC-mediated Multidrug Resistance(MDR), and (iii) investigate the signaling pathways involved in ABC transportermediated MDR. Method: We utilized Poly Lactic-co-Glycolic Acid (PLGA) nanoparticles as a co-delivery system for SC-514 and 3-Bromopyruvate (3-BPA) in LNCaP cells. The impact of varying concentrations of these drugs on LNCaP cells was studied. Bioassays used included Trypan Blue, MTT, and NBT. Fluorescence microscopy was performed. Results: A One-way ANOVA was conducted to compare 3-BPA, SC-514, and the combination of 3-BPA and SC-514 after 24 hours of treatment. The result shows that the p-value= 0.00023. Regression analysis of the results from the time-dependent experiments was performed. The regression analysis showed the following p-values: 24hrs (0.00023), 48hrs (0.00003), 72hrs (0.000000152), 96hrs (0.000000049). ROS levels of LNCaP cells treated with 3-BPA (r=-0.5), SC-514 (r=- 0.72) and 3-BPA + SC-514 (r=-0.58) were compared using one-way ANOVA. The result showed no significant difference in ROS modulation (p=0.54). Conclusion: There is a weak to moderate correlation between ROS levels and cell death. Additionally, there was a positive correlation between the drug concentrations and cell death.
- Pain Medicine, Pain Management, Pain Medications
Location: Webinar
Chair
Toluleke Famuyiwa
Florida Atlantic University, USA
Session Introduction
Shreya Goswami
Vivekananda Institute of Medical Sciences, India
Title: Pectoral nerve block1 versus modified pectoral nerve block2 for postoperative pain relief in patients undergoing modified radical mastectomy: A randomized clinical trial
Biography:
Shreya Goswami completed her Medical School from Institute of Post Graduate Medical Education & Research in 2010. She completed her Residency in Anesthesia and Critical Care from Vivekananda Institute of Medical Sciences in the year 2017. During her tenure as a resident, she received a Gold medal for best paper from the state of West Bengal in Sarojini Devi Memorial Paper Presentation, ISAJAC, 2015. She also represented her state at the national level in the prestigious Dr TN Jha Memorial Paper Presentation and received Dr KP Chansoria travel grant in ISACON, Jaipur, India, 2015. As a resident, her work on PECs block was published in the British Journal of Anesthesia. A part of the study was presented in the World Congress of Anesthesia in Hong Kong 2016 and the abstract was published in Anesthesia & Analgesia. She is currently a Senior Resident in Vivekananda Institute of Medical Sciences, Kolkata, India..
Abstract:
Background: Pectoral nerve block1 (PEC1) given between pectoralis major and minor, and modified pectoral nerve block2 (mPEC2) performed between pectoralis minor and serratus anterior, can provide continuous analgesia after Modified Radical Mastectomy (MRM) when catheters are placed before skin closure. This study was designed to compare PEC1 and mPEC2 block for providing postoperative pain relief after MRM. Methods: Sixty-two physically fit patients undergoing MRM were assigned into two groups (Group PEC1, n¼31 and Group mPEC2, n¼31). Before wound closure, the epidural catheter was placed in the group designated muscle plane and 30ml of 0.25% bupivacaine was injected through the catheter after wound closure. Bupivacaine 15ml of 0.25% top up was given on patient’s demand or whenever visual analog scale (VAS) score was >4. Time for the First Analgesia (TFA), number of top-ups and VAS was recorded at 0.5, 6, 12, 18, 24h after surgery. Sensory blockade was assessed 30min after extubation. Results: Analgesia was significantly prolonged in group mPEC2 [mean(SD)] 313.45(43.05) vs 258.87(34.71)min in group PEC1, P<0.001. Total pain experienced over 24h was significantly less in group mPEC2 [mean(SD)] 9.77(6.93) than in group PEC1 24.19(10.81), P<0.0001. Consequently, top up requirements were significantly reduced in group mPEC2 than in group PEC1 [median(range)] 3(2-4) vs 4(3-5) respectively, P<0.001. Lateral pectoral (77.42% and 35.48%) and thoracodorsal nerves (93.55% and 48.39%) had a higher incidence of sensory block in group mPEC2 than group PEC1, P<0.001. Conclusions: mPEC2 provides better postoperative analgesia than PEC1 when catheters are placed under direct vision after MRM.
Alahari Pallavi
Andhra University, India
Title: Certain aspects of yoga practices in the management of chronic pain
Biography:
A Pallavi, is working as Asst. Prof. in Physical; Education in Department of Physical Education and Sports Sciences, Andhra University, India. She did her M.Phil. from Annamalai University and Ph.D in Physical Education from Andhra University. She also holds MBA Sports Management, M.Sc. Yoga and M.Sc. Yoga Therapy from Tamilnadu Sports University. She participated and presented research papers in various National and International Seminars and Conferences. Her research papers related to Yoga and Physical Education were published in various journals. She was the recipient of several national awards like Bharat Jyothi Award, Mother Teresa Excellence Award and The Best Citizens of India Award.
Abstract:
Over the years the chronic pain has found a steady place in the famed category of chronic diseases worldwide. Chronic pain is multi-dimensional: At the physical level itself, beyond the nociceptive pathway, there is hyperarousal state of the components of the nervous system, which negatively influences tension component of the muscles, patterns of breathing, energy levels and mindset, all of which exacerbate the distress and affect the quality of life of the individual and family. Beginning with the physical body, Yoga eventually influences all aspects of the person: Vital, mental, emotional, intellectual and spiritual. It offers various levels and approaches to relax, energize, remodel and strengthen body and psyche. The asanas and pranayama harmonize the physiological system and initiate a “relaxation response” in the neuroendocrinal system. This consists of decreased metabolism, quieter breathing, stable blood pressure, reduced muscle tension, lower heart rate, and slow brain wave pattern. As the neural discharge pattern gets modulated, hyperarousal of the nervous system and the static load on postural muscle come down. The function of viscera improves with the sense of relaxation and sleep gets deeper and sustained; fatigue diminishes. Several subtle level notional corrections can happen in case the subject meditates and that changes the context of the disease, pain and the meaning of life. Meditation and pranayama, along with relaxing asanas, can help individuals deal with the emotional aspects of chronic pain, reduce anxiety and depression effectively and improve the quality of life perceived.
Teneshia Spencer
Pinnacle Medical Center, USA
Title: A call for understanding and greater access to balanced
Biography:
Teneshia Spencer is a serial entrepreneur and currently serves as the Chief Executive Officer, Owner, and founder for the following businesses: Pinnacle Primary Care & Wellness Center dba Pinnacle Medical Center, We Care Restorative Foundation, Eastern Urgent Care & Infusion Center & Hot Box Dispensary. He has completed her second master’s at the age of 26 years from the University of Denver and currently working towards her JD/MPH in Law & Medicine at Boston University School of Law. He currently owns and operates as the director of her private practice medical facility Pinnacle Primary Care & Wellness, a premier primary care & wellness center. This will be her first speaking engagement as well as serving as an editorial board member of repute.
Abstract:
Multimodal analgesia offers a patient-specific, balanced approach to treating acute pain, such as that caused by broken bones, surgery, and childbirth. The approach combines two or more pain-relieving treatments or techniques – acting through different mechanisms – to provide better pain relief using fewer opioids. With multimodal analgesia, a patient may receive some combination of IV acetaminophen (in hospital settings), antidepressants, steroids, nerve blocks, epidurals or prescription-strength forms of anti-inflammatory drugs. The approach can also include local injections of analgesia. Integrated Care for Chronic Pain: Similarly, patients who experience chronic pain – such as low back pain, migraine headache or fibromyalgia – can also benefit from a comprehensive approach to pain management. According to studies “Opioids can be effective,” “but they are hardly the only treatment strategy that should be considered.” Physical therapy and rehabilitation, as well as psychosocial treatments to address the emotional and social effects of pain, can complement the use of medication – including over-the-counter, prescription non-opioid and opioid treatments. Access Barriers & Policy Solutions: Balanced pain management can help clinicians move away from a one-size-fits-all approach to pain management, which sometimes favors an opioid-only approach despite patients’ unique needs. One driver behind that approach may be health insurance and hospital formularies that favor low-cost treatments such as generic opioids. Another cause, the paper argues, is health coverage that steers patients toward the lowest-cost treatment through techniques such as step therapy. Despite the upfront expense, a balanced approach can lower care costs over the long term by better managing pain and reducing opioid-related adverse events. With updated formularies, improved insurance coverage and more education, patients and their healthcare providers can achieve better pain management. The approach can also aid national efforts to curb the opioid abuse epidemic. Safe Use & Disposal: Finally, no conversation about pain management is complete without discussing the safe use and disposal of pain medications. This white oral report acknowledges the importance of safe prescribing, comprehensive labeling, and safeguards such as medicine cabinet inventories, safe storage and responsible disposable of unused drugs.
Amani Abu-Shaheen
King Fahad Medical City, Saudi Arabia
Title: Validity and reliability of the Arabic version of the ID pain screening questionnaire in the assessment of neuropathic pain
Biography:
Amani Abu-Shaheen is a senior clinical researcher with extensive experience in the healthcare sector. She earned her Master's in Public Health/Epidemiology in 2007 from the Jordan University of Science & Technology. Since 2009 she joined King Fahad Medical City Research Center where she worked with researchers on writing and editing of different manuscripts and proposals, reviewing journals, abstracts, and scientific literature. Her research interest focuses on pain management and clinical trials as well.
Abstract:
Introduction: Diagnosis of Neuropathic Pain (NP) can be challenging. The ID Pain (ID-P) questionnaire, a screening tool for NP, has been translated into several languages and is widely used. However, ID-P validation process has not been done in the Arab population. The ID-P tool appears to accurately indicate the presence of a neuropathic component of pain. This simple tool, which can be self-administered, could be of immense use in primary care settings. Thus, the aim of this study was to develop an Arabic version of ID-P and assess its validity and reliability in detecting neuropathic pain. Methods: The original ID-P was translated in Arabic language and administered to the study population. The adaptation procedure was monitored by a seven-member expert panel including two specialists in pain management, an expert in methodology, an expert in clinical research, and an expert in linguistics. Patients were divided into two groups. The first group included patients diagnosed with NP by a pain specialist in pain clinics as per the guidelines established by the IASP, whereas the second study group included patients with Nociceptive Pain (NocP). The Arabic version of the ID-Pain was administered twice to the study population, by the same investigator. Reliability of the Arabic version was evaluated by percentage observed agreement, and Cohen's Kappa; and validity by sensitivity, specificity, correctly classified, and Receiver Operating Characteristic (ROC) curve. Physician diagnosis was considered as the gold standard for comparing the diagnostic accuracy. Results: The study included 375 adult patients (153 [40.8%] with NP; 222 [59.2%] with nociceptive pain). Overall observed percentage agreement and Cohen's kappas were >90% and >0.80, respectively. Median (range) score of the ID-P scale was 3 (2±4) and 1 (0±2) in the NP group and NocP group, respectively (p<0.001). The area under the ROC curve was 0.808 (95% CI, 0.764±0.851). For the cut-off value of _2, sensitivity was 84.3%, specificity was 66.7%, and correct classification was 73.9%. Thus, the Arabic version of ID-P showed moderate reliability and validity as a pain assessment tool. Conclusions: This article presents the psychometric properties of the Arabic version of ID Pain questionnaire. This Arabic version may serve as a simple yet important screening tool, and help inappropriate management of neuropathic pain, specifically in primary care centers.