Abraham Flores Vargas
Hospital General de México, Mexico
Title: OCD in animal models using quinpirole as dopaminergic inductor of perseverative behaviour
Biography
Biography: Abraham Flores Vargas
Abstract
In the reviewed articles, quinpirole is used as a dopamine D2 and D3 receptor agonist to induce persistent behavior in animal models. Dopamine has been related to perseverative behavior also has been related with the perseption of pain and relief. The perseverative behavior was observed in an open field with objects of different shapes and sizes. The main structures studied with this methodology are the orbitofrontal cortex, striatum, thalamus, basolateral amygdala and nucleus accumbens. The animal models studied comply with the face, predictive and construct validity. We think this topic is important because the content of the article shows the right structure and methodology also how to evaluate and compare the information in different articles this method can be applied at any topic; we have focused in the face, predictive and construct validity. It is important to mention that this reviewed article had and extensive search in the website of Pubmed although there were only a few information of the topic which it is a reason for us to continue investigating and providing new information related.