Rômulo José Soares Bezerra
Oswaldo Cruz Institute – FIOCRUZ, Brazil
Title: The P2X7R activation and its correlation with the inflammatory and nociceptive signaling: A promising target for the treatment of painful diseases
Biography
Biography: Rômulo José Soares Bezerra
Abstract
The search for new medicines with less side effects and more efficacy to treat the pain states and inflammatory diseases continues to be a challenge difficult to solve. In this context, the search of new molecules with antagonistic action on the P2X7 receptor (P2X7R), which is a purinergic receptor that is physiologically activated by ATP released from apoptotic or necrotic cells during an inflammatory process, emerge as a promising therapy. Since its activation promotes the release of pro-inflammatory and pro-nociceptive cytokines, i.e. IL-1β and other inflammatory mediators as NO and ROS. Our group has been focusing in the context of the High Throughput Screening of Natural Products to find a possible new analgesic and anti-inflammatory compound with antagonistic profile on the P2X7R. Actually, we found three compounds with such in vitro and in vivo activities.