Alen J Salerian
The Salerian Center and Doctors for Equal Rights for Physical and Mental Pain, USA
Title: Endorphins and endorphin agonists for pain, addiction, depression and psychosis
Biography
Biography: Alen J Salerian
Abstract
Salerian Center for Neuroscience and Pain is a private institution in Washington DC with a dual mission of Hippocratic medicine and science. This presentation reviews endorphins and endorphin agonists in treatment of chronic pain, addiction, depression chronic pain with depression and psychosis with endorphins as the common crucial variable. There is compelling evidence that endorphins and endorphin agonists are of vital importance in the genesis and treatment of chronic pain, addiction, depression, chronic pain with depression and psychosis. This presentation reviews biology of regional brain dysfunction, neurotransmitters, mechanism of action of antidepressant strategies, preclinical data over antidepressant effects of endorphins, clinical data of antidepressant effects of endorphins, common pathways of pain and depression and addresses common challenges associated with therapeutic interventions with endorphin like substances. The engineering of slow-release endorphins agonists have enabled possible effective treatments for diverse neuropsychiatric conditions with relatively low risk of overuse or adverse events. Further double-blind studies will be helpful to validate these findings.