9^th International Anesthesia and Pain Medicine Conference

Novel Therapeutic Approaches for Pain Medicine

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Ketamine (INN) could be a medication used primarily for beginning and maintaining anesthesia. Alternative uses includes sedation in Intensive Care as a pain killer as treatment of bronchosspasm, as a treatment for Complex regional pain syndrome and as a treatment for complex Regional Pain Syndrome and as an antidepressant. It induces a trance like state whereas providing pain relief sedation and memory loss. Pharmacologically, Ketamine is assessed as an NMDA receptor antagonist, however it additionally acts at varied alternative sites (including opioid receptors and monoamine transporters). Like alternative drugs in its category, such as phencyclidine (PCP), it's classified as a dissociative agent. Ketamine is also used for surgical pain management. Low doses of ketamine reduce morphine use and nausea and Vomiting after surgery.  Top quality evidence in acute pain is insufficient to determine if ketamine is useful during this situation. It may even be used as an Intravenous analgesic with opiates to manage otherwise Intractable pain, significantly if this pain is neuropathic. It is the additional advantage of counteracting spinal sensitization or wind-up phenomena experienced with chronic pain management. At these doses, the Psychotropic side effects are less apparent and well managed with benzodiazepines. Ketamine is an analgesic that is most effective when used alongside a low-dose opioid; as whereas it will have analgesic effects by itself, the higher doses needed will cause disorienting aspect effects. A review in 2013 concluded, "Despite limitations in the breadth and depth of data available. there's proof that ketamine may be a viable option for treatment-refractory cancer pain".Low-dose ketamine hydrochloride is typically utilized in the treatment of Complex regional pain syndrome (CRPS).